Abstract
AbstractWe report an efficient higher order conjugate addition of azauracils to substituted para-quinone methides (p-QMs) mediated by triethylamine to furnish hitherto unknown diarylmethane scaffolds through construction of a C–N bond. The protocol features mild conditions, high atom economy, and broad scope, and enables convenient access to biologically relevant new chemical entities (NCEs) comprised of p-QM and azauracil hybrids in good to excellent yields.
Funder
Science and Engineering Research Board
Council of Scientific and Industrial Research, India
Department of Science and Technology
University Grants Commission
Subject
Organic Chemistry,Catalysis
Cited by
3 articles.
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