Affiliation:
1. Department of Chemistry Indian Institute of Technology Jodhpur Karwar 342037 Rajasthan India
Abstract
AbstractA visible light‐induced green and sustainable N−H functionalization of (aza)uracils with α‐diazo esters leading to imide alkylation is described. The reaction does not require any catalyst or additive and proceeds under mild conditions. Moreover, an intriguing three component coupling was observed when (aza)uracils were allowed to react with α‐diazo esters in cyclic ethers (e. g. 1,4‐dioxane, THF) as a solvent. Both the insertion and three‐component coupling features broad scope with good to excellent yields and appreciable functional group tolerance. Notably, the divergent method enables modification of natural products and pharmaceuticals, thereby facilitates access to potentially biologically active compounds.
Funder
Science and Engineering Research Board
Subject
General Chemistry,Biochemistry,Organic Chemistry