Diterpenoids from Leaves of Cultivated Plectranthus ornatus-Reference-Cited by-同舟云学术

Diterpenoids from Leaves of Cultivated Plectranthus ornatus

Published:2020-08-03 Issue:01/02 Volume:87 Page:124-135
ISSN:0032-0943
Container-title:Planta Medica
language:en
Short-container-title:Planta Med

Author:

Mesquita Lidivânia Silva Freitas¹,Matos Taynara Simão¹,Ávila Fábio do Nascimento¹,Batista Alison da Silva¹,Moura Andréa Felinto²,de Moraes Manoel Odorico²,da Silva Matheus Carlos Matos³,Ferreira Talles Luann Abrantes³,Nascimento Nilberto Robson Falcão³,Monteiro Norberto Kássio Vieira⁴,Pessoa Otília Deusdênia Loiola¹

Affiliation:

1. Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil

2. Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil

3. Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil

4. Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Fortaleza-CE, Brazil

Abstract

AbstractTwo new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1209-3252.pdf

Reference42 articles.

1. Plectranthus: a review of ethnobotanical uses;C W Lukhoba;J Ethnopharmacol,2006

2. Plectranthus: A plant for the future?;L J Rice;South African J Bot,2011

3. Volatile-oils composition, and bioactivity of the essential oils of Plectranthus barbatus, P. neochilus, and P. ornatus grown in Portugal;L Mota;Chem Biodivers,2014

4. Rosmarinic and cinnamic acid derivatives of in vitro tissue culture of Plectranthus ornatus: overproduction and correlation with antioxidant activities;H H Medrado;J Braz Chem Soc,2017

5. Antimicrobial properties of Plectranthus ornatus extracts, 11-acetoxyhalima-5,13-dien-15-oic acid metabolite and its derivatives;P Rijo;Nat Prod J,2011

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Halimane Derivatives from Plectranthus ornatus Codd. as Novel Anti-cancer Agents;Biomedicine & Pharmacotherapy;2024-05

2. Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells;ACS Omega;2024-04-08

3. Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings;Molecules;2023-07-26

4. The chemical composition of the aerial parts essential oil of Plectranthus ornatus growing wild in Israel;Natural Product Research;2023-05-24

5. Biological screening of herbal extracts and essential oil from Plectranthus species: α-amylase and 5-lipoxygenase inhibition and antioxidant and anti-Candida potentials;Brazilian Journal of Pharmaceutical Sciences;2023