Author:
Jin Zhichao,Ren Shi-Chao,Peng Xiaolin,Wang Yulin,Huang Yixian,Zhang Sheng
Abstract
AbstractThe synthesis of polysubstituted 4H-pyran derivatives has attracted considerable attention due to its wide application in agrochemicals, pharmaceuticals, and other functional molecules. We report an N-heterocyclic carbene-catalyzed [3+3] annulation reaction of β-ketone esters with enynals for rapid access to pentasubstituted 4H-pyran derivatives through a regioselective activation of the ynal. A series of 4H-pyran derivatives bearing various substituents were obtained in moderate to excellent yields. This method could find further applications in the synthesis of structurally diverse 4H-pyran-derived functional molecules from readily available starting materials.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Science and Technology Department of Guizhou Province
National Natural Science Fund for Excellent Young Scientists Fund Program