Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors-Reference-Cited by-同舟云学术

Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors

Published:2018-12 Issue:22 Volume:26 Page:5934-5943
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Zheng Xuehua,Jiang Zan,Li Xiaolin,Zhang Chen,Li Zhe,Wu Yinuo,Wang Xinhua,Zhang Chao,Luo Hai-bin,Xu Jun,Wu Deyan^ORCID

Funder

Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Medical Scientific Research Foundation of Guangdong Province

Science and Technology Program of Guangzhou, China

Guangdong Provincial Key Laboratory of Construction Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference48 articles.

1. AKR1C3 as a target in castrate resistant prostate cancer

2. Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy

3. Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer

4. Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis

5. Expression of steroidogenic enzymes and sex-steroid receptors in human prostate

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