Affiliation:
1. Graduate School of Pharmaceutical Sciences, Tohoku University
2. Department of Chemistry, The University of Tokyo and JST,
ERATO, Isobe Degenerate π-Integration Project, Hongo 7-3-1
Abstract
A new synthetic route to functionalized 9,10-diarylanthracenes has been developed. 9,10-Epoxyanthracene intermediates were prepared by [4+2] cycloaddition of 1,3-diarylisobenzofuran with a variety of functionalized benzyne intermediates, which were obtained by Mg(TMP)2·2LiCl-mediated benzyne generation. For the cleavage of the resultant 9,10-epoxyanthracene intermediates, we developed mild deoxygenation conditions using a combination of trifluoroacetic acid and Et3SiH. The utility of this sequence was demonstrated by application to the synthesis of 5,7,12,14-tetraphenylpentacene.
Cited by
12 articles.
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