One-Pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes via a Mercury-Carbene Intermediate-Reference-Cited by-同舟云学术

One-Pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes via a Mercury-Carbene Intermediate

Published:2017-05-15 Issue:18 Volume:49 Page:4173-4182
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zhu Shifa¹²,Zheng Min¹,Chen Kai¹

Affiliation:

1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology

2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University

Abstract

The cyclization of nitroalkyne catalyzed by Hg(OTf)2 to produce the corresponding benzo[c]isoxazole in excellent yields with high selectivity is reported. On the basis of this strategy, a one-pot method to synthesize indole derivatives has been developed. In this transformation, two Hg-carbene intermediates are proposed to be involved.

Funder

Ministry of Science and Technology of the People’s Republic of China

Natural Science Foundation of China

Guangdong Natural Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588416.pdf

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Photocatalyst/metal-free sequential C–N/C–S bond formation: Synthesis of S-arylisothioureas via photoinduced EDA complex activation;Chinese Chemical Letters;2024-11

2. Ligand‐free CuO nanoparticles catalyzed S‐arylation of heterocyclic thiols using aryl halides;Applied Organometallic Chemistry;2024-05-30

3. Additive-free synthesis of S-substituted isothioureas via visible-light-induced four-component reaction of α-diazoesters, aryl isothiocyanates, amines and cyclic ethers;Chinese Chemical Letters;2024-02

4. Base/DMSO‐Promoted Synthesis of Benzo[4,5]imidazo[2,1‐a]isoquinolines via C−C Bond Formation;Advanced Synthesis & Catalysis;2024-01-23

5. TMSOTf-Catalyzed Reactions of N-Arylynamides with Sulfilimines To Construct 2-Aminoindoles and α-Arylated Amidines;The Journal of Organic Chemistry;2024-01-05