Affiliation:
1. Department of Pure and Applied Chemistry
2. Sanofi Germany
Abstract
AbstractA highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.
Funder
University of Strathclyde
Carnegie Trust for the Universities of Scotland