HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease

Author:

Sazonovs Aleksejs,Kennedy Nicholas A.,Moutsianas LoukasORCID,Heap Graham A.,Rice Daniel L.,Reppell Mark,Bewshea Claire M.,Chanchlani NeilORCID,Walker Gareth J.,Perry Mandy H.,McDonald Timothy J.,Lees Charlie W.,Cummings J.R. Fraser,Parkes Miles,Mansfield John C.,Irving Peter M.,Barrett Jeffrey C.,McGovern Dermot,Goodhand James R.,Anderson Carl A.,Ahmad Tariq,Patel Vinod,Mazhar Zia,Saich Rebecca,Colleypriest Ben,Tham Tony C,Iqbal Tariq H,Kaushik Vishal,Murugesan Senthil,Singh Salil,Weaver Sean,Preston Cathryn,Butt Assad,Smith Melissa,Basude Dharamveer,Beale Amanda,Langlands Sarah,Direkze Natalie,Parkes Miles,Torrente Franco,De La Revella Negro Juan,Ewen MacDonald Chris,Evans Stephen M,Gunasekera Anton V J,Thakur Alka,Elphick David,Shenoy Achuth,Nwokolo Chuka U,Dhar Anjan,Cole Andrew T,Agrawal Anurag,Bridger Stephen,Doherty Julie,Cooper Sheldon C,de Silva Shanika,Mowat Craig,Mayhead Phillip,Lees Charlie,Jones Gareth,Ahmad Tariq,Hart James W,Gaya Daniel R,Russell Richard K,Gervais Lisa,Dunckley Paul,Mahmood Tariq,Banim Paul J R,Sonwalkar Sunil,Ghosh Deb,Phillips Rosemary H,Azaz Amer,Sebastian Shaji,Shenderey Richard,Armstrong Lawrence,Bell Claire,Hariraj Radhakrishnan,Matthews Helen,Jafferbhoy Hasnain,Selinger Christian P,Zamvar Veena,De Caestecker John S,Willmott Anne,Miller Richard,Sathish Babu Palani,Tzivinikos Christos,Bloom Stuart L,Chung-Faye Guy,Croft Nicholas M,Fell John ME,Harbord Marcus,Hart Ailsa,Hope Ben,Irving Peter M,Lindsay James O,Mawdsley Joel E,McNair Alistair,Monahan Kevin J,Murray Charles D,Orchard Timothy,Paul Thankam,Pollok Richard,Shah Neil,Bouri Sonia,Johnson Matt W,Modi Anita,Dawa Kabiru Kasamu,Baburajan B K,Bhaduri Bim,Adebayo Fagbemi Andrew,Levison Scott,Limdi Jimmy K,Watts Gill,Foley Stephen,Ramadas Arvind,MacFaul George,Mansfield John,Grellier Leonie,Morris Mary-Anne,Tremelling Mark,Hawkey Chris,Kirkham Sian,Charlton Charles PJ,Rodrigues Astor,Simmons Alison,Lewis Stephen J,Snook Jonathon,Tighe Mark,Goggin Patrick M,De Silva Aminda N,Lal Simon,Smith Mark S,Panter Simon,Cummings Fraser,Dharmisari Suranga,Carter Martyn,Watts David,Mahmood Zahid,McLain Bruce,Sen Sandip,Pigott Anna J,Hobday David,Wesley Emma,Johnston Richard,Edwards Cathryn,Beckly John,Vani Deven,Ramakrishnan Subramaniam,Chaudhary Rakesh,Trudgill Nigel J,Cooney Rachel,Bell Andy,Prasad Neeraj,Gordon John N,Brookes Matthew J,Li Andy,Gore Stephen

Funder

AbbVie

Merck Sharp & Dohme

NAPP Pharmaceuticals Ltd

Pfizer

Celltrion Healthcare

Cure Crohn’s Colitis

Wellcome Trust

National Institute for Health Research

Publisher

Elsevier BV

Subject

Gastroenterology,Hepatology

Reference27 articles.

1. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn’s disease: a prospective, multicentre, cohort study;Kennedy;Lancet Gastroenterol Hepatol,2019

2. Immunogenicity of biologics in inflammatory bowel disease;Vermeire;Therap Adv Gastroenterol,2018

3. Infliximab, azathioprine, or combination therapy for Crohn’s disease;Colombel;N Engl J Med,2010

4. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis;Panaccione;Gastroenterology,2014

5. Adalimumab monotherapy and a combination with azathioprine for Crohn’s disease: a prospective, randomized trial;Matsumoto;J Crohns Colitis,2016

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