von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD-Reference-Cited by-同舟云学术

von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD

Published:2019-12-13 Issue:24 Volume:3 Page:4147-4154
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Atiq Ferdows¹^ORCID,Schütte Lisette M.¹,Looijen Agnes E. M.¹,Boender Johan¹,Cnossen Marjon H.²^ORCID,Eikenboom Jeroen³⁴^ORCID,de Maat Moniek P. M.¹^ORCID,Kruip Marieke J. H. A.¹,Leebeek Frank W. G.¹^ORCID

Affiliation:

1. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

2. Department of Pediatric Hematology, Erasmus University Medical Center–Sophia Children’s Hospital, Rotterdam, The Netherlands; and

3. Division of Thrombosis and Hemostasis, Department of Internal Medicine and

4. Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Key Points VWF and FVIII levels after desmopressin, which mimic hemostatic response, are associated with the bleeding phenotype of type 1 VWD patients. Variability in VWF and FVIII response to hemostatic challenges may partly explain heterogeneity in bleeding phenotype of VWD patients.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/24/4147/1549819/advancesadv2019000863.pdf

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