Significant gynecological bleeding in women with low von Willebrand factor levels

Author:

Lavin Michelle12ORCID,Aguila Sonia2,Dalton Niall2,Nolan Margaret1,Byrne Mary1,Ryan Kevin1,White Barry1,O’Connell Niamh M.1,O’Sullivan Jamie M.2,Di Paola Jorge3,James Paula D.4,O’Donnell James S.12ORCID

Affiliation:

1. National Coagulation Centre, St. James’s Hospital, Dublin, Ireland;

2. Irish Centre for Vascular Biology, Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland;

3. Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; and

4. Department of Medicine, Queen’s University, Kingston, ON, Canada

Abstract

Key Points BATs differ significantly in sensitivity for detecting menorrhagia in women with low VWF. Despite pregnancy-related increases in plasma VWF levels, significant PPH may occur in women with low VWF.

Publisher

American Society of Hematology

Subject

Hematology

Reference32 articles.

1. Hereditar psuedohemofili;von Willebrand;Fin Lakaresallsk Handl.,1926

2. Committee opinion no.580: von Willebrand disease in women;Committee on Adolescent Health Care; Committee on Gynecologic Practice;Obstet Gynecol,2013

3. Gynaecological and obstetric bleeding in moderate and severe von Willebrand disease;De Wee;Thromb Haemost,2011

4. Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders;Kadir;Haemophilia,1999

5. Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey;Kouides;Haemophilia,2000

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