SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells-Reference-Cited by-同舟云学术

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells

Published:2023-05-24 Issue:11 Volume:7 Page:2317-2323
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Hara Yannis¹²^ORCID,Lemgart Viktor T.³,Halland Nis⁴^ORCID,Mahdaviani Kiana⁵,Ribeil Jean-Antoine⁵^ORCID,Lessard Samuel²⁶^ORCID,Hicks Alexandra¹²,Light David R.²^ORCID

Affiliation:

1. 1Immunology and Inflammation, Sanofi, Cambridge, MA

2. 2Rare Blood Disorders, Sanofi, Waltham, MA

3. 3Tidal Therapeutics, Cambridge, MA

4. 4Integrated Drug Discovery, Sanofi, Frankfurt, Germany

5. 5Sickle Cell Center of Excellence, Boston University Medical Center, Boston, MA

6. 6Precision Medicine and Computational Biology, Sanofi, Framingham, MA

Publisher

American Society of Hematology

Subject

Hematology

Link

https://ashpublications.org/bloodadvances/article-pdf/7/11/2317/2056757/blooda_adv-2022-008710-main.pdf

Reference27 articles.

1. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells;Zhang;Blood,2018

2. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis;Halland;J Med Chem,2022

3. Fetal hemoglobin in sickle cell anemia;Steinberg;Blood,2020

4. Pathophysiology of Sickle Cell Disease;Sundd;Annu Rev Pathol,2019

5. Sickle cell disease: current treatment and emerging therapies;Neumayr;Am J Manag Care,2019

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1. Elevating fetal hemoglobin: recently discovered regulators and mechanisms;Blood;2024-08-22