Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells-Reference-Cited by-同舟云学术

Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells

Published:2018-07-19 Issue:3 Volume:132 Page:321-333
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Yankai¹,Paikari Alireza¹,Sumazin Pavel¹,Ginter Summarell Carly C.¹,Crosby Jacy R.²³,Boerwinkle Eric⁴,Weiss Mitchell J.⁵,Sheehan Vivien A.¹^ORCID

Affiliation:

1. Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston TX;

2. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX;

3. Department of Biostatistics, Bioinformatics, and Systems Biology and

4. Department of Epidemiology, Human Genetics and Environmental Health, University of Texas Health Sciences Center, Houston, TX; and

5. St. Jude Children’s Research Hospital, Memphis, TN

Abstract

Key Points Functional studies in human primary erythroid progenitor cells support a role for FOXO3 in γ-globin regulation. Metformin treatment of human primary erythroid progenitor cells increases fetal hemoglobin in a partially FOXO3-dependent manner.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/3/321/1372440/blood814335.pdf

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