Significant differences in single-platelet biophysics exist across species but attenuate during clot formation

Author:

Oshinowo Oluwamayokun1234ORCID,Copeland Renee1234,Sakurai Yumiko1234,Fay Meredith E.1234,Petrich Brian G.2,Leong Traci5,Brainard Benjamin6ORCID,Lam Wilbur A.1234ORCID

Affiliation:

1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA;

2. Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children’s Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA;

3. Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA;

4. Winship Cancer Institute and

5. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA; and

6. Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA

Abstract

Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar. Multiple biophysical parameters integrate during clot formation, measured by bulk clot contraction, and attenuate biophysical differences.

Publisher

American Society of Hematology

Subject

Hematology

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