Elevated hematocrit enhances platelet accumulation following vascular injury

Author:

Walton Bethany L.1,Lehmann Marcus2,Skorczewski Tyler3,Holle Lori A.1,Beckman Joan D.4,Cribb Jeremy A.5,Mooberry Micah J.4,Wufsus Adam R.2,Cooley Brian C.6,Homeister Jonathan W.1,Pawlinski Rafal46,Falvo Michael R.5,Key Nigel S.46ORCID,Fogelson Aaron L.78,Neeves Keith B.29,Wolberg Alisa S.16ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC;

2. Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO;

3. Department of Mathematics and Statistics, Cornell College, Mount Vernon, IA;

4. Division of Hematology/Oncology, Department of Medicine,

5. Department of Physics and Astronomy, and

6. McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC;

7. Department of Mathematics and

8. Department of Bioengineering, University of Utah, Salt Lake City, UT; and

9. Department of Pediatrics, University of Colorado–Denver, Aurora, CO

Abstract

Key Points Elevated hematocrit promotes arterial thrombus formation. During arterial thrombosis, elevated hematocrit enhances platelet accumulation at the site of vessel injury.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference61 articles.

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2. Blood viscosity in tube flow: dependence on diameter and hematocrit;Pries;Am J Physiol,1992

3. Rheology of blood;Errill;Physiol Rev,1969

4. Hyperviscosity in polycythemia vera and other red cell abnormalities;Kwaan;Semin Thromb Hemost,2003

5. Evaluation of hemostasis in flowing blood;Grabowski;Am J Hematol,2012

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