Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

Author:

Shah Nirali N.1ORCID,Qin Haiying1,Yates Bonnie1,Su Ling2,Shalabi Haneen1,Raffeld Mark3,Ahlman Mark A.4,Stetler-Stevenson Maryalice5,Yuan Constance5ORCID,Guo Shuang2,Liu Siyuan2,Hughes Stephen H.6ORCID,Fry Terry J.178ORCID,Wu Xiaolin2ORCID

Affiliation:

1. Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD;

2. Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD;

3. Molecular Diagnostics Section, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD;

4. Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD;

5. Flow Cytometry, Department of Pathology, NCI, NIH, Bethesda, MD;

6. HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD;

7. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO; and

8. Center for Cancer and Blood Disorders, Children’s Hospital Colorado, Aurora, CO

Abstract

Key Points Reexpansion of CAR T cells led to further investigations which confirmed the clonal nature of this expansion.

Publisher

American Society of Hematology

Subject

Hematology

Cited by 92 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3