Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults-Reference-Cited by-同舟云学术

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Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults

Published:2017-06-22 Issue:25 Volume:129 Page:3322-3331
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gardner Rebecca A.¹²³^ORCID,Finney Olivia¹,Annesley Colleen¹²³^ORCID,Brakke Hannah¹,Summers Corinne¹²,Leger Kasey¹,Bleakley Marie²⁴,Brown Christopher¹,Mgebroff Stephanie¹,Kelly-Spratt Karen S.¹,Hoglund Virginia¹,Lindgren Catherine¹,Oron Assaf P.³,Li Daniel⁵,Riddell Stanley R.⁴⁶,Park Julie R.¹²³,Jensen Michael C.¹²⁴

Affiliation:

1. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA;

2. Department of Pediatrics, University of Washington, Seattle, WA;

3. Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, WA;

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

5. Clinical Statistics Group, Juno Therapeutics, Inc., Seattle, WA; and

6. Department of Medicine, University of Washington, Seattle, WA

Abstract

Publisher's Note: There is an Inside Blood Commentary on this article in this issue.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/25/3322/1364282/blood769208.pdf

Reference19 articles.

1. Chimeric antigen receptor T cells for sustained remissions in leukemia;Maude;N Engl J Med,2014

2. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial;Lee;Lancet,2015

3. CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients;Turtle;J Clin Invest,2016

4. Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells;Turtle;Sci Transl Med,2016

5. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia;Porter;Sci Transl Med,2015

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