Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution-Reference-Cited by-同舟云学术

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution

Published:2017-11-02 Issue:24 Volume:1 Page:2206-2216
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Hiwarkar Prashant¹²,Hubank Mike³,Qasim Waseem¹⁴,Chiesa Robert⁵,Gilmour Kimberly C.⁶,Saudemont Aurore⁷⁸,Amrolia Persis J.¹⁵,Veys Paul¹⁵

Affiliation:

1. Molecular and Cellular Immunology Section, University College London Institute of Child Health, London, United Kingdom;

2. Department of Haematology and Bone Marrow Transplantation, Royal Manchester Children’s Hospital, Manchester, United Kingdom;

3. Genetics and Genomic Medicine Programme, University College London Institute of Child Health, London, United Kingdom;

4. Department of Immunology,

5. Department of Bone Marrow Transplantation, and

6. Laboratory Immunology, Great Ormond Street Hospital for Children, London, United Kingdom;

7. Anthony Nolan Research Institute, London, United Kingdom; and

8. University College London Cancer Institute, Royal Free Campus, London, United Kingdom

Abstract

Key Points Cord blood T cells are ontogenetically distinct from the peripheral blood T cells. Recapitulation of fetal ontogeny after cord blood transplantation results in rapid CD4+ T-cell reconstitution.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/24/2206/879180/advances010827.pdf

Reference39 articles.

1. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny;Mackall;Blood,1993

2. Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments;Ge;Proc Natl Acad Sci USA,2002

3. Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant;Chiesa;Br J Haematol,2012

4. Immune reconstitution assessed during five years after allogeneic bone marrow transplantation;Fujimaki;Bone Marrow Transplant,2001

5. Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome;Lindemans;Blood,2013

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