Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome-Reference-Cited by-同舟云学术

Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome

Published:2014-01-02 Issue:1 Volume:123 Page:126-132
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lindemans Caroline A.¹,Chiesa Robert²,Amrolia Persis J.²,Rao Kanchan²,Nikolajeva Olga²,de Wildt Arianne¹,Gerhardt Corinne E.¹,Gilmour Kimberly C.³,B. Bierings Marc¹,Veys Paul²,Boelens Jaap J.¹⁴

Affiliation:

1. Pediatric Blood and Bone Marrow Program, University Medical Center Utrecht, The Netherlands;

2. Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, United Kingdom;

3. Utrecht–Dendritic Cells against Cancer, Tumorimmunology, Laboratory Translational Immunology, University Medical Center Utrecht, The Netherlands; and

4. Immunology Department, Great Ormond Street Hospital, London, United Kingdom

Abstract

Key Points For good immune reconstitution and fewer viral reactivations, thymoglobulin should be omitted in cord blood transplants. Because omission of thymoglobulin is associated with higher acute GVHD rates, further improvement of outcome may require individualized dosing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/1/126/1373280/126.pdf

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