Drag-reducing polymers improve hepatic vaso-occlusion in SCD mice-Reference-Cited by-同舟云学术

Drag-reducing polymers improve hepatic vaso-occlusion in SCD mice

Published:2020-09-11 Issue:18 Volume:4 Page:4333-4336
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Crompton Dan¹²,Vats Ravi¹³,Pradhan-Sundd Tirthadipa³^ORCID,Sundd Prithu¹³⁴^ORCID,Kameneva Marina V.¹²⁵

Affiliation:

1. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA;

2. McGowan Center for Regenerative Medicine, Pittsburgh, PA;

3. Pittsburgh Heart, Lung and Blood Vascular Medicine Institute and

4. Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; and

5. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

Abstract

Key Points Nanomolar concentrations of drag-reducing polymer (DRP) reduce vaso-occlusion in the liver of sickle cell disease (SCD) mice. The potential for DRP as a rheology-based treatment/therapy for SCD warrants further study.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/18/4333/1758758/advancesadv2020002779.pdf

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4. Sickle-cell disease;Rees;Lancet,2010

5. The cost of health care for children and adults with sickle cell disease;Kauf;Am J Hematol,2009

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2. High-molecular-weight linear polymers improve microvascular perfusion after extracorporeal circulation;Journal of Applied Physiology;2024-01-01

3. Hemorheological Approach to Improve Perfusion of Red Blood Cells with Reduced Deformability Using Drag-Reducing Polymer (In Vitro Study);ASAIO Journal;2021-08-16