High-molecular-weight linear polymers improve microvascular perfusion after extracorporeal circulation-Reference-Cited by-同舟云学术

High-molecular-weight linear polymers improve microvascular perfusion after extracorporeal circulation

Published:2024-01-01 Issue:1 Volume:136 Page:213-223
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Govender Krianthan¹^ORCID,Walser Cynthia¹^ORCID,Cabrales Pedro¹^ORCID

Affiliation:

1. Functional Cardiovascular Engineering Laboratory, University of California San Diego, La Jolla, California, United States

Abstract

High-molecular-weight linear polymers have gained traction in bioengineering applications. The addition of PEG3500k to lactated Ringer solution (LR) improved microvascular blood flow in arterioles and venules acutely after extracorporeal circulation (ECC) in a hamster model and improved functional capillary density up to 24 h after ECC. PEG3500k improved venular hemoglobin O2 saturation and oxygen delivery acutely after ECC and reduced inflammation in various organs compared to LR alone.

Funder

HHS | National Institutes of Health

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00397.2023

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