Identification of a tumor-specific allo-HLA–restricted γδTCR-Reference-Cited by-同舟云学术

Identification of a tumor-specific allo-HLA–restricted γδTCR

Published:2019-10-04 Issue:19 Volume:3 Page:2870-2882
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Kierkels G. J. J.¹,Scheper W.¹,Meringa A. D.¹,Johanna I.¹,Beringer D. X.¹,Janssen A.¹,Schiffler M.¹,Aarts-Riemens T.¹,Kramer L.¹,Straetemans T.¹,Heijhuurs S.¹,Leusen J. H. W.¹^ORCID,San José E.²^ORCID,Fuchs K.³,Griffioen M.³,Falkenburg J. H.³,Bongiovanni L.⁴^ORCID,de Bruin A.⁴,Vargas-Diaz D.⁵⁶,Altelaar M.⁵⁶^ORCID,Heck A. J. R.⁵⁶^ORCID,Shultz L. D.⁷,Ishikawa F.⁸^ORCID,Nishimura M. I.⁹,Sebestyén Z.¹,Kuball J.¹¹⁰

Affiliation:

1. Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;

2. Facultad de Ciencias Biomédicas y Salud, Universidad Europea, Madrid, Spain;

3. Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands;

4. Department of Pathobiology, Faculty of Veterinary Medicine, Dutch Molecular Pathology Center, Utrecht University, Utrecht, The Netherlands;

5. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, and

6. Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands;

7. Department of Immunology, The Jackson Laboratory, Bar Harbor, ME;

8. Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;

9. Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL; and

10. Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

Key PointsWe describe a novel allo-tumor–reactive and CD8α-dependent Vγ5Vδ1TCR. The molecular interface with proximity to the peptide-binding groove of HLA-A*24:02 is an essential determinant of recognition.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/19/2870/1223990/advances032409.pdf

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