Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation

Author:

Henden Andrea S.123ORCID,Varelias Antiopi2ORCID,Leach Justine1,Sturgeon Elise1,Avery Judy1,Kelly Jessica1,Olver Stuart2,Samson Luke2,Hartel Gunter4ORCID,Durrant Simon1,Butler Jason1,Morton Anthony J.1,Misra Ashish1,Tey Siok-Keen12ORCID,Subramoniapillai Elango1,Curley Cameron1,Kennedy Glen1,Hill Geoffrey R.1256

Affiliation:

1. Department of Haematology and Bone Marrow Transplantation, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia;

2. Bone Marrow Transplantation Laboratory, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, QLD, Australia;

3. Faculty of Medicine, University of Queensland, Herston, QLD, Australia;

4. Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;

5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

6. Division of Medical Oncology, The University of Washington, Seattle, WA

Abstract

Key Points Peg-IFNα is tolerated and induces disease response in patients who relapse after allogeneic SCT. Increased pretreatment MAIT and pDC proportions were associated with better progression-free and overall survival after peg-IFNα treatment.

Publisher

American Society of Hematology

Subject

Hematology

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