CD4 + CD25 + Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation-Reference-Cited by-同舟云学术

CD4 + CD25 + Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation

Published:2010-07-21 Issue:41 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Maury Sébastien¹²,Lemoine François M.³⁴,Hicheri Yosr¹²,Rosenzwajg Michelle³⁴,Badoual Cécile⁵⁶,Cheraï Mustapha³⁴,Beaumont Jean-Louis⁷,Azar Nabih³,Dhedin Nathalie⁸,Sirvent Anne⁹,Buzyn Agnès¹⁰,Rubio Marie-Thérèse¹⁰,Vigouroux Stéphane¹¹,Montagne Olivier²¹²,Bories Dominique¹²,Roudot-Thoraval Françoise²¹³,Vernant Jean-Paul⁸,Cordonnier Catherine¹²,Klatzmann David³⁴,Cohen José L.⁴⁸

Affiliation:

1. Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

2. Université Paris-Est Créteil Val de Marne, Créteil F-94010, France.

3. Department of Biotherapies, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.

4. Centre National de la Recherche Scientifique UMR 7211, Université Pierre et Marie Curie Paris 06, Paris F-75013, France.

5. Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris F-75015, France.

6. Ecole Nationale Vétérinaire d’Alfort, EA4054, Paris Descartes University, Paris F-75005, France.

7. Department of Hemapheresis, Etablissement Français du Sang d’Ile de France, Créteil F-94010, France.

8. Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.

9. Department of Hematology, Hôpital Archet, Nice F-06000, France.

10. Department of Hematology, Hôpital Necker, Paris F-75015, France.

11. Department of Hematology, Hôpital Haut-Leveque, Bordeaux F-33000, France.

12. Center for Clinical Investigation in Biotherapy, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

13. Department of Public Health, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.

Abstract

Immunological effects of donor lymphocyte infusion for treatment of recurrent malignancy after allogeneic hematopoietic cell transplantation can be enhanced by depleting T regulatory cells in the infused cells and in the recipient.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

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3. Graft-versus-leukemia effects of transplantation and donor lymphocytes

4. Graft-versus-leukemia reactions after bone marrow transplantation

5. Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

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