Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors

Author:

Nagelkerke Sietse Q.12,Bruggeman Christine W.12,den Haan Joke M. M.3,Mul Erik P. J.24,van den Berg Timo K.12,van Bruggen Robin12,Kuijpers Taco W.125

Affiliation:

1. Department of Blood Cell Research, Sanquin Research, Amsterdam, The Netherlands;

2. Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

3. Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands;

4. Department of Central Facility Research, Sanquin Research, Amsterdam, The Netherlands; and

5. Department of Pediatric Hematology, Immunology & Infectious Disease, Emma Children’s Hospital at the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Human red pulp macrophages are distinct from monocytes and monocyte-derived macrophages in the expression of FcγRs and other surface markers. Red pulp macrophages phagocytose IgG-opsonized blood cells by activating FcγRs and are sensitive to IV immunoglobulin blocking

Publisher

American Society of Hematology

Subject

Hematology

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