Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma-Reference-Cited by-同舟云学术

Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma

Published:2019-09-30 Issue:19 Volume:3 Page:2790-2799
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Chiu Brian C.-H.¹^ORCID,Zhang Zhou²,You Qiancheng³,Zeng Chang²^ORCID,Stepniak Elizabeth⁴,Bracci Paige M.⁵,Yu Kangkang³,Venkataraman Girish⁶,Smith Sonali M.⁷,He Chuan³⁸,Zhang Wei²⁹

Affiliation:

1. Department of Public Health Sciences, University of Chicago, Chicago, IL;

2. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL;

3. Department of Chemistry and

4. Comprehensive Cancer Center, University of Chicago, Chicago, IL;

5. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA;

6. Department of Pathology and

7. Section of Hematology/Oncology, Department of Medicine, and

8. Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and Howard Hughes Medical Institute, University of Chicago, Chicago, IL; and

9. The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL

Abstract

Key Points Genome-wide 5hmC loci can be profiled in 1 to 2 ng of cfDNA from blood plasma and correlate with clinical features of DLBCL. 5hmC in cfDNA collected at the time of DLBCL diagnosis is associated with EFS and OS, independent of established prognostic factors.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/19/2790/1223962/advancesadv2019000175.pdf

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