Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice-Reference-Cited by-同舟云学术

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

Published:2018-02-26 Issue:4 Volume:2 Page:414-427
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Schutt Steven D.¹,Wu Yongxia¹,Tang Chih-Hang Anthony²,Bastian David¹,Nguyen Hung¹,Sofi M. Hanief¹,Zhang MengMeng¹³,Liu Chen⁴,Helke Kris⁵,Wilson Carole⁶,Schnapp Lynn M.⁶,Del Valle Juan R.⁷,Hu Chih-Chi Andrew²,Yu Xue-Zhong¹⁶

Affiliation:

1. Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC;

2. Department of Translational Tumor Immunology, The Wistar Institute, Philadelphia, PA;

3. Department of Hematology, Xiangya Hospital, Changsha, China;

4. Department of Pathology and Laboratory Medicine, Rutgers–Robert Wood Johnson Medical School, New Brunswick, NJ;

5. Department of Comparative Medicine and

6. Department of Medicine, Medical University of South Carolina, Charleston, SC; and

7. Department of Chemistry, University of South Florida, Tampa, FL

Abstract

Key Points Targeting XBP-1 on B cells is sufficient to prevent cGVHD. Pharmacologic inhibition of IRE-1α/XBP-1 prevents cGVHD while preserving GVL activity.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/4/414/880438/advances009068.pdf

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4. IRE1α-XBP1 signaling pathway, a potential therapeutic target in multiple myeloma;Chen;Leuk Res,2016

5. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1;Iwakoshi;Nat Immunol,2003

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