IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy-Reference-Cited by-同舟云学术

IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy

Published:2022-03-07 Issue:4 Volume:19 Page:1059-1067
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Shao Andong¹,Xu Qin¹,Kang Chang Won²,Cain Christopher F.²,Lee Avery C.¹,Tang Chih-Hang Anthony¹,Del Valle Juan R.²^ORCID,Hu Chih-Chi Andrew¹^ORCID

Affiliation:

1. Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, Texas 77030, United States

2. Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00639

Reference21 articles.

1. Endoplasmic Reticulum Stress and the Hallmarks of Cancer

2. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

3. Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

4. Synthesis of Novel Tricyclic Chromenone-Based Inhibitors of IRE-1 RNase Activity

5. IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

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