Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation-Reference-Cited by-同舟云学术

Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation

Published:2019-12-19 Issue:24 Volume:3 Page:4215-4227
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Stevens Alexandra M.¹^ORCID,Xiang Michael²^ORCID,Heppler Lisa N.²,Tošić Isidora²³^ORCID,Jiang Kevin²,Munoz Jaime O.¹,Gaikwad Amos S.¹,Horton Terzah M.¹,Long Xin¹,Narayanan Padmini¹,Seashore Elizabeth L.¹,Terrell Maci C.¹,Rashid Raushan¹,Krueger Michael J.¹,Mangubat-Medina Alicia E.⁴,Ball Zachary T.⁴^ORCID,Sumazin Pavel¹,Walker Sarah R.²⁵,Hamada Yoshimasa⁶⁷,Oyadomari Seiichi⁶⁷,Redell Michele S.¹^ORCID,Frank David A.²⁵^ORCID

Affiliation:

1. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX;

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Biochemistry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia;

4. Department of Chemistry, Rice University, Houston, TX;

5. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and

6. Division of Molecular Biology, Institute for Genome Research, and

7. Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

Abstract

Key Points Atovaquone induces AML blast apoptosis and prolongs survival in AML xenografts. Atovaquone induces proapoptotic signaling and inhibits the mTOR pathway through upregulation of ATF4 and also suppresses OXPHOS.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/24/4215/1549441/advancesadv2019000499.pdf

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