Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent-Reference-Cited by-同舟云学术

Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

Published:2016-10-06 Issue:14 Volume:128 Page:1845-1853
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Xiang Michael¹,Kim Haesook²,Ho Vincent T.¹³,Walker Sarah R.¹³,Bar-Natan Michal¹,Anahtar Melodi¹,Liu Suhu¹,Toniolo Patricia A.¹,Kroll Yasmin¹,Jones Nichole¹,Giaccone Zachary T.¹,Heppler Lisa N.¹,Ye Darwin Q.¹,Marineau Jason J.¹,Shaw Daniel¹,Bradner James E.¹,Blonquist Traci²,Neuberg Donna²,Hetz Claudio⁴⁵,Stone Richard M.¹³,Soiffer Robert J.¹³,Frank David A.¹³

Affiliation:

1. Department of Medical Oncology and

2. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and

4. Geroscience Center for Brain Health and Metabolism and

5. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile

Abstract

Key PointsThe FDA-approved drug atovaquone is a novel, clinically available inhibitor of STAT3 at standard human plasma concentrations. Atovaquone shows anticancer efficacy in vitro, in vivo, and in a retrospective study of AML patient outcomes after atovaquone treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/14/1845/1396109/1845.pdf

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4. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.;Nelson;Blood,2008

5. STAT3 as a central mediator of neoplastic cellular transformation.;Frank;Cancer Lett,2007

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