Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Link
https://www.nature.com/articles/s41416-023-02394-9.pdf
Reference14 articles.
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2. Xu Y, Xue D, Bankhead A, Neamati N. Why all the fuss about oxidative phosphorylation (OXPHOS)? J Med Chem. 2020;63:14276–307.
3. Janku F, LoRusso P, Mansfield AS, Nanda R, Spira A, Wang T, et al. First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer. Invest N Drugs. 2021;39:1348–56.
4. Yap TA, Daver N, Mahendra M, Zhang J, Kamiya-Matsuoka C, Meric-Bernstam F, et al. Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials. Nat Med. 2023;29:115–26.
5. Boreel DF, Span PN, Heskamp S, Adema GJ, Bussink J. Targeting oxidative phosphorylation to increase the efficacy of radio- and immune-combination therapy. Clin Cancer Res. 2021;27:2970–8.
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