Updated international consensus report on the investigation and management of primary immune thrombocytopenia

Author:

Provan Drew1ORCID,Arnold Donald M.2,Bussel James B.3,Chong Beng H.4ORCID,Cooper Nichola5,Gernsheimer Terry6,Ghanima Waleed78ORCID,Godeau Bertrand9,González-López Tomás José10,Grainger John11ORCID,Hou Ming12,Kruse Caroline13,McDonald Vickie14,Michel Marc9,Newland Adrian C.1,Pavord Sue15,Rodeghiero Francesco16,Scully Marie17,Tomiyama Yoshiaki18,Wong Raymond S.19,Zaja Francesco20,Kuter David J.21

Affiliation:

1. Academic Haematology Unit, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;

2. McMaster Centre for Transfusion Research, Department of Medicine and Department of Pathology and Molecular Medicine, McMaster University and Canadian Blood Services, Hamilton, ON, Canada;

3. Division of Hematology/Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY;

4. St. George Hospital, NSW Health Pathology, University of New South Wales, Sydney, NSW, Australia;

5. Department of Haematology, Hammersmith Hospital, London, United Kingdom;

6. Seattle Cancer Care Alliance, University of Washington, Seattle, WA;

7. Departments of Research, Medicine and Oncology, Østfold Hospital Trust, Grålum, Norway;

8. Department of Hematology, Institute of Clinical Medicine, Oslo University, Oslo, Norway;

9. Centre de Référence des Cytopénies Auto-Immunes de l'Adulte, Service de Médecine Interne, CHU Henri Mondor, AP-HP, Université Paris-Est Créteil, Créteil, France;

10. Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain;

11. Department of Haematology, Royal Manchester Children’s Hospital, Manchester, United Kingdom;

12. Department of Haematology, Qilu Hospital, Shandong University, Jinan, China;

13. Platelet Disorder Support Association, Cleveland, OH;

14. Royal London Hospital, Barts Health NHS Trust, London, United Kingdom;

15. Haematology Theme Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom;

16. Hematology Project Foundation, Affiliated to the Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy;

17. Department of Haematology, University College London Hospital, Cardiometabolic Programme-NIHR UCLH/UCL BRC, London, United Kingdom;

18. Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan;

19. Sir YK Pao Centre for Cancer and Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong;

20. SC Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste, Italy; and

21. Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Abstract

Abstract Over the last decade, there have been numerous developments and changes in treatment practices for the management of patients with immune thrombocytopenia (ITP). This article is an update of the International Consensus Report published in 2010. A critical review was performed to identify all relevant articles published between 2009 and 2018. An expert panel screened, reviewed, and graded the studies and formulated the updated consensus recommendations based on the new data. The final document provides consensus recommendations on the diagnosis and management of ITP in adults, during pregnancy, and in children, as well as quality-of-life considerations.

Publisher

American Society of Hematology

Subject

Hematology

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