Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major-Reference-Cited by-同舟云学术

Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major

Published:2017-11-28 Issue:25 Volume:1 Page:2421-2432
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Huo Yongliang¹²,Lockhart Jonathan R.¹^ORCID,Liu Shanrun¹,Fontenard Suean¹,Berlett Mike¹,Ryan Thomas M.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL; and

2. Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China

Abstract

Key Points After completion of the fetal-to-adult globin gene switch, humanized β-thalassemia major mice are transfusion dependent. Perinatal humanized β-thalassemia major mice are rescued by bone marrow transplantation in the absence of cytoreductive conditioning.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/25/2421/879425/advances009449.pdf

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