The impact of response kinetics for multiple myeloma in the era of novel agents

Author:

Yan Yuting1,Mao Xuehan1,Liu Jiahui1,Fan Huishou1,Du Chenxing1,Li Zengjun1,Yi Shuhua1,Xu Yan1,Lv Rui1,Liu Wei1,Deng Shuhui1,Sui Weiwei1,Wang Qi1,Zou Dehui1,Wang Jianxiang1,Cheng Tao1,Zhan Fenghuang2,Tai Yu-Tzu3,Yuan Chenglu4,Du Xin5,Qiu Lugui1,Anderson Kenneth C.3,An Gang145

Affiliation:

1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China;

2. Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, University of Iowa, Iowa City, IA;

3. LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

4. Qilu Hospital of Shandong University (Qing dao), Qingdao, China; and

5. Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China

Abstract

Key Points Early responders with MM (TBR ≤3 months) are more likely to have higher lactate dehydrogenase levels and experience inferior outcomes. The kinetic pattern of response is a simple and powerful predictor for survival of patients with MM even in the era of novel agents.

Publisher

American Society of Hematology

Subject

Hematology

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