MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial

Author:

Zhu Hong-Hu1,Zhang Xiao-Hui1,Qin Ya-Zhen1,Liu Dai-Hong1,Jiang Hao1,Chen Huan1,Jiang Qian1,Xu Lan-Ping1,Lu Jin1,Han Wei1,Bao Li1,Wang Yu1,Chen Yu-Hong1,Wang Jing-Zhi1,Wang Feng-Rong1,Lai Yue-Yun1,Chai Jun-Yue2,Wang Li-Ru3,Liu Yan-Rong1,Liu Kai-Yan1,Jiang Bin1,Huang Xiao-Jun14

Affiliation:

1. Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China;

2. Beijing No.6 Hospital, Beijing, China;

3. Beijing Rehabilitation Hospital, Beijing, China; and

4. Peking-Tsinghua Center for Life Sciences, Beijing, China

Abstract

Key Points Risk stratification treatment of t(8;21) acute myeloid leukemia may decrease relapse and improve long-term survival. Allo-HSCT benefited high-risk patients, but impaired the survival of low-risk patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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