Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways-Reference-Cited by-同舟云学术

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways

Published:2017-09-08 Issue:20 Volume:1 Page:1749-1759
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Gough Sheryl M.¹,Goldberg Liat¹,Pineda Marbin¹,Walker Robert L.¹,Zhu Yuelin J.¹,Bilke Sven¹,Chung Yang Jo¹,Dufraine Joseph¹,Kundu Subhadip¹,Jacoby Elad²,Fry Terry J.²,Fischer Susanna³,Panzer-Grümayer Renate³⁴,Meltzer Paul S.¹,Aplan Peter D.¹

Affiliation:

1. Genetics Branch and

2. Pediatric Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

3. Leukemia Biology Group, Children’s Cancer Research Institute, Vienna, Austria; and

4. Department of Pediatrics, Medical University of Vienna, Vienna, Austria

Abstract

Key Points An NUP98-PHF23 fusion collaborates with acquired Bcor and Jak/Stat mutations to produce a pro–B-1 ALL. Gene expression profile of murine pro–B-1 ALL resembles that of a subset of human ALL, suggesting some human ALLs arise from pro–B-1 B cells.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/20/1749/878771/advances009837.pdf

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4. Human b1 cell frequency: isolation and analysis of human b1 cells;Griffin;Front Immunol,2012

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