VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites-Reference-Cited by-同舟云学术

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites

Published:2018-03-26 Issue:6 Volume:2 Page:691-702
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Czogalla Katrin J.¹,Liphardt Kerstin¹,Höning Klara²,Hornung Veit²³,Biswas Arijit¹,Watzka Matthias¹⁴,Oldenburg Johannes¹⁴

Affiliation:

1. Institute of Experimental Haematology and Transfusion Medicine and

2. Institute of Molecular Medicine, University Clinic Bonn, Bonn, Germany;

3. Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany; and

4. Center for Rare Diseases Bonn, University Clinic Bonn; Bonn, Germany

Abstract

Key Points VKORC1 is more sensitive than VKORC1L1 to OAC inhibition, whereby 4-hydroxycoumarin rodenticides are equally effective. In silico and in vitro analysis revealed OAC binding sites that are different for VKORC1 and VKORC1L1.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/6/691/882980/advances006775.pdf

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5. Current pharmacogenetic developments in oral anticoagulation therapy: the influence of variant VKORC1 and CYP2C9 alleles;Oldenburg;Thromb Haemost,2007

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