Bone marrow transplantation prevents right ventricle disease in the caveolin-1–deficient mouse model of pulmonary hypertension-Reference-Cited by-同舟云学术

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Bone marrow transplantation prevents right ventricle disease in the caveolin-1–deficient mouse model of pulmonary hypertension

Published:2017-03-17 Issue:9 Volume:1 Page:526-534
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Asosingh Kewal¹,Wanner Nicholas¹,Weiss Kelly¹,Queisser Kimberly¹,Gebreab Liya²,Kassa Biruk²,Stuehr Eric¹,Graham Brian²,Erzurum Serpil¹³

Affiliation:

1. Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH;

2. Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO; and

3. Department of Pathobiology, Respiratory Institute, The Cleveland Clinic, Cleveland, OH

Abstract

Key Points Caveolin-1 deficiency in hematopoietic stem cells induces right heart disease. Healthy BM protects the right heart from maladaptation.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/9/526/878294/advances002691.pdf

Reference38 articles.

1. Molecular pathogenesis of pulmonary arterial hypertension;Rabinovitch;J Clin Invest,2012

2. Caveolin, a protein component of caveolae membrane coats;Rothberg;Cell,1992

3. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles;Kurzchalia;J Cell Biol,1992

4. The caveolae membrane system;Anderson;Annu Rev Biochem,1998

5. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases;Li;J Biol Chem,1996

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