Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer‐like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Author:

Spiekerkoetter Edda1,Goncharova Elena A.23ORCID,Guignabert Christophe4ORCID,Stenmark Kurt56,Kwapiszewska Grazyna7,Rabinovitch Marlene8,Voelkel Norbert9,Bogaard Harm J.9,Graham Brian10,Pullamsetti Soni S.1112,Kuebler Wolfgang M.13141516

Affiliation:

1. Division of Pulmonary and Critical Care MedicineWall Center for Pulmonary Vascular DiseaseCardiovascular InstituteStanford UniversityStanfordCAUSA

2. Pittsburgh Heart, Blood and Vascular Medicine InstitutePulmonary, Allergy & Critical Care DivisionDepartment of MedicineUniversity of PittsburghPittsburghPAUSA

3. Department of BioengineeringUniversity of PittsburghPittsburghPAUSA

4. INSERM UMR_S 999Université Paris‐SudUniversité Paris‐SaclayLe Kremlin‐BicêtreFrance

5. Department of PediatricsSchool of MedicineUniversity of ColoradoDenverCOUSA

6. Cardio Vascular Pulmonary Research LabUniversity of ColoradoDenverCOUSA

7. Ludwig Boltzmann InstituteLung Vascular ResearchMedical University of GrazGrazAustria

8. Division of Pediatric CardiologyWall Center for Pulmonary Vascular DiseaseCardiovascular InstituteStanford UniversityStanfordCAUSA

9. Department of Pulmonary MedicineVrije Universiteit MCAmsterdamThe Netherlands

10. Pulmonary Sciences and Critical CareSchool of MedicineUniversity of ColoradoDenverCOUSA

11. Max Planck Institute for Heart and Lung ResearchBad NauheimGermany

12. Department of Internal MedicineUniversities of Giessen and Marburg Lung Center (UGMLC)GiessenGermany

13. Institute of PhysiologyCharité – Universitaetsmedizin BerlinBerlinGermany

14. The Keenan Research Centre for Biomedical Science at St. Michael'sTorontoONCanada

15. Department of SurgeryUniversity of TorontoTorontoONCanada

16. Department of PhysiologyUniversity of TorontoTorontoONCanada

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference167 articles.

1. Pathogenesis of pulmonary arterial hypertension: lessons from cancer;Guignabert C;Eur Respir Rev,2013

2. The cancer theory of pulmonary arterial hypertension;Boucherat O;Pulm Circ,2017

3. The cancer paradigm of severe pulmonary arterial hypertension;Rai PR;Am J Respir Crit Care Med,2008

4. Molecular pathogenesis and current pathology of pulmonary hypertension;Perez VA;Heart Fail Rev,2016

5. Pulmonary arterial hypertension: pathogenesis and clinical management;Thenappan T;BMJ,2018

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