Haploidentical transplant in patients with myelodysplastic syndrome

Author:

Robin Marie1,Porcher Raphael23,Ciceri Fabio4,van Lint Maria Teresa5,Santarone Stella6,Ehninger Gerhard7,Blaise Didier8,Güllbas Zafer9,Gonzáles Muñiz Soledad10,Michallet Mauricette11,Velardi Andrea12,Koster Linda13,Maertens Johan14,Sierra Jorge15,Selleslag Dominik16,Radujkovic Aleksandar17,Díez-Martin José L.18,Kanz Lothar19,Arroyo Concepcion Herrera20,Niederwieser Dietger21,Huang He22,McDonald Andrew23,de Witte Theo24,Koc Yener25,Kröger Nicolaus26

Affiliation:

1. Hospital Saint-Louis, Assistance Publique Hôpitaux de Paris, INSERM 1131, University Paris 7, Paris, France;

2. Team methods, Epidemiology and Statistics Sorbonne Paris Cité Research Centre, Unité Mixte de Recherche 1153, INSERM, Paris Descartes University, Paris, France;

3. Epidemiology Center, Assistance Publique Hôpitaux de Paris, Hôpital Hôtel-Dieu, Paris, France;

4. Division of Hematology/Oncology, Department of Internal Medicine, San Raffaele Hospital, Milan, Italy;

5. Department of Hematology, San Martino Hospital, Genoa, Italy;

6. Department of Hematology, Civil Hospital, Pescara, Italy;

7. Division of Hematology, Department of Internal Medicine, Dresden University Hospital, Dresden, Germany;

8. Department Hematology, Paoli Calmettes Institute, Marseille, France;

9. Hematologic Oncology and Bone Marrow Transplantation Unit, Anadolu Medical Center Hospital, Kocaeli, Turkey;

10. Division of Hematology/Oncology, Asturias Central University Hospital, Oviedo, Spain;

11. Department of Hematology, Lyon Sud Hospital, Lyon, France;

12. Division of Hematology and Clinical Immunology, Perugia University, Perugia, Italy;

13. European Group for Blood and Marrow Transplantation Data Office, Leiden, The Netherlands;

14. Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium;

15. Department of Internal Medicine, Hospital Santa Creu i Sant Pau, Barcelona, Spain;

16. A.Z. Sint-Jan, Brugge, Belgium;

17. Division of Hematology/Oncology, Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany;

18. Department of Hematology, Gregorio Marañon General University Hospital, Madrid, Spain;

19. Department of Hematology/Immunology/Oncology, Universität Tübingen, Tübingen, Germany;

20. Department of Hematology, Hospital Reina Sofia Córdoba Hospital, Córdoba, Spain;

21. Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany;

22. Department of Hematology, First Affiliated Hospital, Zhejiang University, Hangzhou Zhejiang, China;

23. Department of Hematology, Netcare Pretoria East Hospital, Pretoria Gauteng, South Africa;

24. Department of Hematopoietic Diseases, Radboud University Medical Center, Nijmegen, The Netherlands;

25. Stem Cell Transplant Unit, Medical Park Hospitals, Antalya, Turkey; and

26. Department of Hematology/Oncology, University Hospital Eppendorf, Hamburg, Germany

Abstract

Key Points Nonrelapse mortality remains high in MDS patients who underwent haploidentical transplant before 2015. Haplotransplantation using PT-CY and reduced-intensity conditioning seems an acceptable option in MDS patients lacking HLA-matched donors.

Publisher

American Society of Hematology

Subject

Hematology

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