Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma-Reference-Cited by-同舟云学术

Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma

Published:2001-05-01 Issue:9 Volume:97 Page:2900-2902
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Drayson Mark¹,Tang Lian X.¹,Drew Roger¹,Mead Graham P.¹,Carr-Smith Hugh¹,Bradwell Arthur R.¹

Affiliation:

1. From the Department of Immunology, The Medical School, University of Birmingham, Birmingham, England, and The Binding Site, Birmingham, England.

Abstract

Abstract Using sensitive, automated immunoassays, increased concentrations of either κ or λ free light chains (and abnormal κ/λ ratios) were detected in the sera of 19 of 28 patients with nonsecretory multiple myeloma. Four other patients had suppression of one or both light chains, and the remaining 5 sera had normal or raised free light-chain concentrations with substantially normal κ/λ ratios. Six of the patients with an elevated single free light chain, who were studied during follow-up, had changes in disease activity that were reflected by the changes in free light-chain concentrations. It is concluded that quantification of free light chains in serum should prove useful for the diagnosis and monitoring of many patients with nonsecretory myeloma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/97/9/2900/1673621/h8090102900.pdf

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3. Demonstration of serum monoclonal immunoglobulin in a case of non-secretory myeloma by immunoisoelectric focusing.;Sheehan;J Clin Pathol.,1985

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