Gadd45a regulates hematopoietic stem cell stress responses in mice-Reference-Cited by-同舟云学术

Gadd45a regulates hematopoietic stem cell stress responses in mice

Published:2014-02-06 Issue:6 Volume:123 Page:851-862
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Yulin¹,Ma Xiaoming¹,Zhang Meimei¹,Wang Xiaomin²,Wang Changxin¹,Wang Hu¹,Guo Peng¹,Yuan Weiping²,Rudolph Karl Lenhard³,Zhan Qimin⁴,Ju Zhenyu¹

Affiliation:

1. Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, China;

2. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;

3. Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany; and

4. State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Abstract

Key Points Loss of Gadd45a enhances HSC reconstitution on hematopoietic stress. Gadd45a regulates DNA damage responses in HSCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/6/851/1378692/851.pdf

Reference28 articles.

1. Hematopoiesis: an evolving paradigm for stem cell biology.;Orkin;Cell,2008

2. DNA damage response in adult stem cells: pathways and consequences.;Mandal;Nat Rev Mol Cell Biol,2011

3. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.;Rossi;Nature,2007