Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg2269.pdf
Reference117 articles.
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3. Rando, T. A. Stem cells, ageing and the quest for immortality. Nature 441, 1080–1086 (2006).
4. Janzen, V. et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443, 421–426 (2006). This paper and references 65 and 66 demonstrate a general role for the p16 gene in the onset of ageing-dependent functional deficits in three different adult stem cell and/or progenitor cell models. It also highlights the fact that cancer prevention and ageing are two sides of the same coin.
5. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer and cancer stem cells. Nature 414, 105–111 (2001).
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