A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites-Reference-Cited by-同舟云学术

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites

Published:2014-01-23 Issue:4 Volume:123 Page:582-589
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Haque Jamil A.¹,McDonald Matthew G.¹,Kulman John D.²³,Rettie Allan E.¹

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA;

2. Puget Sound Blood Center, Seattle, WA; and

3. Division of Hematology, University of Washington School of Medicine, Seattle, WA

Abstract

Key Points Factor IX glutamyl carboxylation in engineered HEK 293 cells recapitulates in vivo anticoagulant inhibition of vitamin K cycle activity. Warfarin metabolite structure-activity analysis on vitamin K cycle antagonism determines their contributions to in vivo anticoagulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/4/582/1378948/582.pdf

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