The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA

Author:

Schlenk Richard F.1,Taskesen Erdogan2,van Norden Yvette3,Krauter Jürgen4,Ganser Arnold4,Bullinger Lars1,Gaidzik Verena I.1,Paschka Peter1,Corbacioglu Andrea1,Göhring Gudrun5,Kündgen Andrea6,Held Gerhard7,Götze Katharina8,Vellenga Edo9,Kuball Juergen10,Schanz Urs11,Passweg Jakob12,Pabst Thomas13,Maertens Johan14,Ossenkoppele Gert J.15,Delwel Ruud2,Döhner Hartmut1,Cornelissen Jan J.2,Döhner Konstanze1,Löwenberg Bob2

Affiliation:

1. Department of Internal Medicine III, University of Ulm, Ulm, Germany;

2. Department of Hematology and

3. Department of Trials and Statistics, Erasmus University Medical Center, Rotterdam, The Netherlands;

4. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation and

5. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany;

6. Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany;

7. Department of Internal Medicine, University of Homburg, Homburg, Germany;

8. Department of Internal Medicine III, University of Munich, Munich, Germany;

9. Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, The Netherlands;

10. Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands;

11. Division of Hematology, University Hospital, Zürich, Switzerland;

12. Department of Hematology, University Hospital, Basel, Switzerland;

13. Department of Hematology, University Hospital, Bern, Switzerland;

14. Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium; and

15. Division of Hematology, VU University Medical Center, Amsterdam, The Netherlands

Abstract

Key Points In AML with bialleleic CEBPA-mut relapse-free survival was improved by allogeneic and autologous hematopoietic stem cell transplantation. In relapsed patients second complete remission rate was high and survival was favorable after an allogeneic transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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