Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study

Author:

de Rooij Jasmijn D. E.1,Masetti Riccardo2,van den Heuvel-Eibrink Marry M.13,Cayuela Jean-Michel4,Trka Jan5,Reinhardt Dirk6,Rasche Mareike6,Sonneveld Edwin7,Alonzo Todd A.8,Fornerod Maarten1,Zimmermann Martin9,Pigazzi Martina10,Pieters Rob3,Meshinchi Soheil11,Zwaan C. Michel1,Locatelli Franco1213

Affiliation:

1. Pediatric Oncology/Hematology, Erasmus Medical Center–Sophia Children’s Hospital, Rotterdam, The Netherlands;

2. Pediatric Hematology/Oncology, University of Bologna, Bologna, Italy;

3. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;

4. Laboratory of Hematology, University Hospital Saint-Louis, Assistance Publique–Hôpitaux de Paris and EA3518, University Paris Diderot, Paris, France;

5. Pediatric Hematology/Oncology, 2nd Medical School, Charles University, Prague, Czech Republic;

6. Acute Myeloid Leukemia–Berlin-Frankfurt-Munster Study Group, Pediatric Hematology/Oncology, University Hospital Essen, Essen, Germany;

7. Dutch Childhood Oncology Group, The Hague, The Netherlands;

8. Children’s Oncology Group, Monrovia, CA;

9. Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;

10. Onco-Hematology, Dipartimento di Salute della Donna e del Bambino, University of Padova, Padova, Italy;

11. Fred Hutchinson Cancer Research Center, Seattle, WA;

12. Department of Pediatric Hematology/Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù, Rome, Italy; and

13. University of Pavia, Pavia, Italy

Abstract

Key Points NUP98/KDM5A, CBFA2T3/GLIS2, KMT2A-rearrangements, and monosomy 7 are associated with poor outcome; RBM15/MKL1 and others fare better. Screening for NUP98/KDM5A, RBM15/MKL1, CBFA2T3/GLIS2, and KMT2A rearrangements combined with conventional karyotyping is advisable.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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