EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma-Reference-Cited by-同舟云学术

EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma

Published:2016-08-18 Issue:7 Volume:128 Page:948-958
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yan Junli¹,Li Boheng²,Lin Baohong³,Lee Pei Tsung¹,Chung Tae-Hoon¹,Tan Joy¹,Bi Chonglei¹,Lee Xue Ting¹,Selvarajan Viknesvaran⁴,Ng Siok-Bian¹²⁴,Yang Henry¹,Yu Qiang⁵,Chng Wee-Joo¹²³

Affiliation:

1. Cancer Science Institute of Singapore, and

2. Yong Loo Lin School of Medicine, National University of Singapore, Singapore;

3. Department of Haematology-Oncology, National University Cancer Institute of Singapore, and

4. Department of Pathology, National University Health System, Singapore;

5. Department of Cancer Biology and Pharmacology, Genome Institute of Singapore, Agency for Science, Technology, and Research (A*STAR), Biopolis, Singapore

Abstract

Key Points JAK3-mediated phosphorylation of EZH2 resulted in EZH2 oncogenic function independent of its enzymatic activity. Targeted inhibition of JAK3 may be a promising treatment in NK/TL through suppressing noncanonical EZH2 activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/7/948/1397967/948.pdf

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