ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes-Reference-Cited by-同舟云学术

ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

Published:2014-08-28 Issue:9 Volume:124 Page:1473-1480
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Parrilla Castellar Edgardo R.¹,Jaffe Elaine S.²,Said Jonathan W.³,Swerdlow Steven H.⁴,Ketterling Rhett P.¹,Knudson Ryan A.¹,Sidhu Jagmohan S.⁵,Hsi Eric D.⁶,Karikehalli Shridevi⁷,Jiang Liuyan⁸,Vasmatzis George⁹,Gibson Sarah E.⁴,Ondrejka Sarah⁶,Nicolae Alina²,Grogg Karen L.¹,Allmer Cristine¹⁰,Ristow Kay M.¹¹,Wilson Wyndham H.¹²,Macon William R.¹,Law Mark E.¹,Cerhan James R.¹⁰,Habermann Thomas M.¹¹,Ansell Stephen M.¹¹,Dogan Ahmet¹,Maurer Matthew J.¹⁰,Feldman Andrew L.¹^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;

2. Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD;

3. Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA;

4. Division of Hematopathology, University of Pittsburgh Medical Center, Pittsburgh, PA;

5. Department of Pathology and Laboratory Medicine, United Health Services Hospitals, Johnson City/Binghamton, NY;

6. Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH;

7. Department of Pathology and Laboratory Medicine, Centrex Clinical Laboratories, Utica, NY;

8. Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL;

9. Center for Individualized Medicine,

10. Department of Health Sciences Research, and

11. Division of Hematology, Mayo Clinic, Rochester, MN; and

12. Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

Abstract

Key Points ALK-negative ALCLs have chromosomal rearrangements of DUSP22 or TP63 in 30% and 8% of cases, respectively. DUSP22-rearranged cases have favorable outcomes similar to ALK-positive ALCLs, whereas other genetic subtypes have inferior outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/9/1473/1382674/1473.pdf

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