Small cell pattern of ALK‐negative anaplastic large cell lymphoma with double‐hit rearrangements of DUSP22 and TP63-Reference-Cited by-同舟云学术

Small cell pattern of ALK‐negative anaplastic large cell lymphoma with double‐hit rearrangements of DUSP22 and TP63

Published:2024-06-17 Issue:4 Volume:5 Page:798-801
ISSN:2688-6146
Container-title:eJHaem
language:en
Short-container-title:eJHaem

Author:

Niiyama‐Uchibori Yui¹,Mizutani Shinsuke¹,Tsukamoto Taku¹,Okamoto Haruya¹,Ide Daisuke¹,Onishi Akio¹,Kato Daishi¹²,Fujino Takahiro¹,Shimira Yuji¹^ORCID,Miyagawa‐Hayashino Aya³,Konishi Eiichi³,Karube Kennosuke⁴,Nannya Yasuhito⁵⁶,Kuroda Junya¹^ORCID

Affiliation:

1. Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine Kyoto Japan

2. Department of Hematology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan

3. Department of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan

4. Department of Pathology and Laboratory Medicine Nagoya University Graduate School of Medicine Nagoya Japan

5. Division of Hematopoietic Disease Control Institute of Medical Science The University of Tokyo Tokyo Japan

6. Department of Pathology and Tumor Biology Kyoto University Kyoto Japan

Abstract

AbstractIn ALK‐negative anaplastic large cell lymphoma (ALCL), gene rearrangements of DUSP22 and TP63 are considered mutually exclusive. The former predicts a favorable prognosis, while the latter is generally unfavorable. We report the first case of ALK‐negative ALCL in a leukemic phase with small cell pattern transformation, harboring double‐hit rearrangements of the DUSP22 gene by inv(6)(p25q21) and TP63 gene by TBL1XR1‐TP63 inversion. Despite the resistance to chemotherapies, the patient remained in remission with allogeneic stem cell transplantation over 20 months. Recognizing this pathologically and genetically rare condition is needed for prompt diagnosis and therapeutic decision‐making in ALK‐negative ALCL.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jha2.960

Reference15 articles.

1. The Leukemic Phase of ALK-Negative Anaplastic Large Cell Lymphoma Is Associated with CD7 Positivity, Complex Karyotype, TP53 Deletion, and a Poor Prognosis

2. Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

3. ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study

4. DUSP22 rearrangement is associated with distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma

5. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes