Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

Author:

Reinisch Andreas123,Etchart Nathalie124,Thomas Daniel3,Hofmann Nicole A.12,Fruehwirth Margareta12,Sinha Subarna5,Chan Charles K.6,Senarath-Yapa Kshemendra6,Seo Eun-Young6,Wearda Taylor6,Hartwig Udo F.7,Beham-Schmid Christine8,Trajanoski Slave9,Lin Qiong10,Wagner Wolfgang10,Dullin Christian11,Alves Frauke1213,Andreeff Michael14,Weissman Irving L.315,Longaker Michael T.6,Schallmoser Katharina1416,Majeti Ravindra317,Strunk Dirk1218

Affiliation:

1. Stem Cell Research Unit and

2. Division of Hematology and Stem Cell Transplantation, Department of Internal Medicine, Medical University of Graz, Graz, Austria;

3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford University, Stanford, CA;

4. Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria;

5. Department of Computer Science, and

6. Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA;

7. University Medical Center, Third Department of Medicine, Johannes Gutenberg–University, Mainz, Germany;

8. Institute of Pathology and

9. Center for Medical Research, Medical University of Graz, Graz, Austria;

10. Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, Rheinisch-Westfälische Technische Hochschule Aachen University Medical School, Aachen, Germany;

11. Department of Diagnostic and Interventional Radiology, University Medical Center, Goettingen, Germany;

12. Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Goettingen, Germany;

13. Department of Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany;

14. Departments of Stem Cell Transplantation & Cellular Therapy, Molecular Hematology & Therapy, and Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;

15. Departments of Pathology and Developmental Biology, Stanford School of Medicine, Stanford University, Stanford, CA;

16. Department of Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria;

17. Department of Medicine, Division of Hematology, Stanford School of Medicine, Stanford University, Stanford, CA; and

18. Institute for Experimental and Clinical Cell Therapy, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria

Abstract

Key Points Epigenetics and in vivo behavior can distinguish MSCs from different sources. BM-derived MSCs form a hematopoietic niche via a vascularized cartilage intermediate.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3